MedGizmo - MedGizmo: Ingestible Sensors – Devices and Technology
29.11.2015, 08:12   MedGizmo

MedGizmo: Ingestible Sensors – Devices and Technology

This is the second part of our Post. In the first part we looked at some general issues as well as for some news on the subject. Now, we provide information on specific developments and gadgets.

The most widely reported and discussed is this product: Proteus Digital Health Pills

Proteus Digital Health, Inc. developed an ingestible sensor and an on-body wearable sensor; together, they electronically confirm unique ingestions and record the date/time of the ingestion.
Here is a good description of one of the cases (Monitoring Adherence to Tuberculosis Therapy) that provides this picture
 
Other information is available at Proteus Web-site.

ID-Cap
    Patient Friendly - the ID-Cap is a standard gelatin or HPMC capsule with an embedded ingestible wireless sensor that holds the patient's medication.  All the patient does is take their medicine - no extra pill to take.  It looks, tastes, and feels just like an ordinary capsule.
    Medication Friendly - the capsule dissolves just like a normal capsule and does not interact with the medication.
    Pharmacy and Pharmaceutical Manufacturer Friendly - ID-Caps are the same size as standard capsules so they can be filled in standard capsule filling systems. High-volume automatic filling systems for pharmaceutical manufacturers to make millions of doses or low-volume manual filling systems for pharmacists to use ID-Caps for a single prescription.
    Reads Every Dose - Full two-way communications between the ID-Cap and the Hub ensure every dose is detected.  The ID-Cap communications technology has demonstrated extremely high reliability in multiple clinical studies.
    "Self" Powered - the ID-Cap sensor is powered by the patient's own body.
    Leaves No Trace - After the capsule dissolves, the ultra thin, flexible sensor is naturally eliminated through the patient's GI tract.


PillCam COLON from Given Imaging Ltd.

Used for detection of colon polyps in patients after an incomplete optical colonoscopy with adequate preparation and a complete evaluation of the colon was not technically possible
The PillCam COLON video capsule is equipped with two miniature color video cameras (one on each end), a battery and an LED light source; it measures 12 mm X 33 mm. PillCam COLON is designed to be ingested by the patient and transmits 4 or 35 frames per second for approximately 10 hours to a recording device worn by the patient. Data are transferred from the device to a computer. FDA approved


CapsoCam small bowel capsule endoscopy system
The CapsoCam small bowel capsule endoscopy system is the only truly wire-free capsule endoscopy system. CapsoCam uses a panoramic lateral 360º view and has the longest battery life available on the market today. With CapsoCam, all of the images captured are stored on-board and there is no generation or transfer of radio-frequency (RF) signals. Patients are completely free of any form of external devices and the clinician is freed of the expensive purchasing, deploying and maintaining of receiver equipment and other accessories for data retrieval.
  •     No interference with active electronic implants— pacemakers, defibrillators, etc.
  •     No more incomplete examinations with obese or higher BMI patients
  •     No patient preparation in medical facility
  •     No scheduling bottlenecks
  •     No investment in capital equipment purchase
  •     No maintenance costs


Microneedle Pill
Researchers at MIT and Massachusetts General Hospital have devised a novel drug capsule coated with tiny needles that can inject drugs directly into the lining of the stomach after the capsule is swallowed. The Microneedle Pill (mPill) is an ingestible capsule containing radially protruding microneedles to enable the oral delivery of protein therapeutics. The microneedles were positioned radially around the central capsule to maximize tissue interaction given the circumferential nature of the GI tract


Check-Cap Capsule
Ingestible imaging capsule for non-invasive colorectal cancer screening
No preparation, invasive procedures or sedation are required. The patient swallows the Check-Cap capsule and continues his or her daily routine while the capsule travels through the colon. Small amounts of standard contrast agent are taken with meals.
Check-Cap's ultra low dose X-ray Radar device is being designed to create reconstructed 2D and 3D images of the colon. No prior bowel cleansing is needed because its x-rays create 360-degree angular scans that can "see through" intestinal content. Exposure to radiation is minimal and equivalent to a regular chest x-ray. The capsule transmits data to a receiving device attached to the patient's back, where it is stored for a physician's analysis. If nothing is detected, no colonoscopy is necessary. If the 3D images reveal polyps, a therapeutic colonoscopy will be prescribed as needed.


e-Celsius Performance
e-Celsius Performance®, is a miniaturised ingestible electronic pill that wirelessly transmits a continuous measurement of gastrointestinal temperature.

The data are stored on a monitor called e-Viewer Performance®. This device shows alerts if the measurement is outside the desired range. The activation box is used to turn the pill on from standby mode and connect the e-Celsius Performance pill with the monitor for data collection in either real time or by recovery from the internal memory of e-Celsius Performance®. Each monitor can be used with up to three pills at once to enable extended use.


IntelliCap Technology
A digital pill with pH sensors, and can release a drug at specific points in the GI tract based on the changes in pH. But these smart capsules are propelled by the digestive system, so they go where the body wants them to go, and at the body’s pace.
Electronic oral drug delivery system
 - Desired location
 - Desired time
 - Desired amount
The IntelliCap® system acts by real-time wireless drug release guided by the physiology (pH, transit time and temperature) of the gut regions.
Brings together a unique combination of controlled delivery, in-vivo measurement, and communication. These capabilities have proven IntelliCap to be a valuable research tool for the pharmaceutical and food industries. The flexibility and ease-of-use of the IntelliCap system allows studies to be designed and executed quickly within the confines of a standard research unit. And real-time data on GI transit and pH mapping provides valuable added information for interpreting study results.

Smart Capsule from MIT Research

MIT researchers successfully tested the ingestible sensor that could help measure vitals of patients whose skin can't be touched. It takes one or two days for it to pass through a user's digestive tract. It can measure heart and breathing rates. The microphone works like a miniature stethoscope. It measures 2.5cm long and 1cm in diameter. Once inside the patient's digestive tract, it picks up the sounds produced by the heart and lungs and sends them as radio-signals to a receiver within a 10ft (3 metre) range

Smart capsule from Purdue University
May deliver medications directly to the large intestines to target certain medical conditions. Might be used to treat of irritable bowel syndrome, Crohn's disease and a potentially life-threatening bacterial infection called Clostridium difficile in which the body loses natural microorganisms needed to fight infection. The capsule is powered by a capacitor that is charged before use. A switch inside the capsule is activated by a magnet that could be worn on the patient's waist. As the capsule meanders through the intestines it eventually comes close to the magnet, activating the switch and releasing a spring-loaded mechanism that opens the capsule, which delivers the medication. The prototype capsule is about the same size as a 000-size gelatin capsule and is designed to release the powdered medication just before reaching the ileocecal valve, where the small and large intestines meet.


Useful links:
29.11.2015, 08:12   MedGizmo
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