MedGizmo - MedGizmo: Focus on PEMF Treatment of Diabetes-related Complications
13.01.2017, 10:44   MedGizmo

MedGizmo: Focus on PEMF Treatment of Diabetes-related Complications

MedGizmo provides daily updates on latest developments in healthcare wearable technology on our Twitter Feed @MedGizmo and Instagram Feed @MedGizmo. We are also committed to regular summary updates in certain areas. 
At the end of last year, a key policy review was conducted by the Board of Directors of MedGizmo, Inc.; at the meeting on January 5th, the Board unanimously approved our new strategy. We plan to focus activities of our company on exploration, evaluation, development and subsequent sales of medical grade equipment that is based on PEMF technology. We also plan to continue our daily updates on latest developments in healthcare wearable technology on our Twitter Feed, Instagram Feed, and our Facebook Page. 

Our initial focus is Diabetes, since it is one of the biggest problems with Health globally. In our previous posts, we provided brief overviews and significant number of links to Internet resources that are related to diabetes, as well as some of the available in the market and perspective medical devices. 
Recent posting by Healogics, Inc. provides this data in infographics 
  
Please, have a look at our previous posts:
In our MedGizmo PEMF Series  we made an overview of Pulsed Electro Magnetic Field Technology and its use for Healthcare purposes. We also have abundance of links to Internet information on the subject. We plan to continue publications; and to this end - publish a series of posts that relate to latest developments in diabetes treatment with Pulsed Electro Magnetic Field Technology (PEMF). 
The purpose of this first post is to provide information on the research that was done on the subject; we are listing the links to certain resources, including scholarly papers. We hope that this might be a helpful base of data both for medical practitioners and researchers.
BioElectronics Corporation describes the advantages of PEMF in the following way:
"PEMF therapy has been shown to have a number of therapeutic effects. These include reducing inflammation, increasing wound tensile strength, vasodilation, promoting angiogenesis and reducing postoperative pain. These effects result in a decreased need for postoperative pain medication and promotion of wound healing. Cell studies have shown gene families involved in tissue repair up-regulated after PEMF exposure (3). In mouse models of diabetic wounds, PEMF therapy has shown to increase dermal cell proliferation, increase tissue granulation and increase wound healing rates (4). And in human experimental wounds, PEMF treatment with an extended use device decreased healing times from 54 days in control to 39 days in the treated group (5), with advanced wound morphology also seen."
This is illustrated by this case with BioElectronics RecoveryRx® therapy
 
Source: Presentation 
 

Some latest scholarly papers on diabetes and PEMF applications:

Pulsed electromagnetic fields in knee osteoarthritis: a double blind, placebo-controlled, randomized clinical trial.
Gian Luca Bagnato, Giovanni Miceli, Natale Marino, Davide Sciortino and Gian Filippo Bagnato.
This trial aimed to test the effectiveness of a wearable pulsed electromagnetic fields (PEMF) device in the management of pain in knee OA patients. Sixty-six patients were included, and 60 completed the study. After 1 month, PEMF induced a significant reduction in VAS pain and WOMAC scores compared with placebo. Additionally, pain tolerance, as expressed by PPT changes, and physical health improved in PEMF-treated patients.

Effect of pulsed electromagnetic field therapy on prostate volume and vascularity in the treatment of benign prostatic hyperplasia: A pilot study in a canine model. Raffaella Leoci,
Giulio Aiudi, Fabio Silvestre, Elaine Lissner, Giovanni Michele Lacalandra.
Benign prostatic hyperplasia (BPH) is a result of urogenital aging. Recent studies suggest that an age-related impairment of the blood supply to the lower urinary tract plays a role in the development of BPH and thus may be a contributing factor in the pathogenesis of BPH. The canine prostate is a model for understanding abnormal growth of the human prostate gland. We studied the efficacy of pulsed electromagnetic field therapy (PEMF) in dogs to modify prostate blood flow and evaluated its effect on BPH. The 3 weeks of PEMF produced a significant reduction in prostatic volume (average 57%) without any interference with semen quality, testosterone levels or libido. The efficacy of PEMF on BPH in dogs, with no side effects, suggests the suitability of this treatment in humans.

How electromagnetic fields can influence adult stem cells: positive and negative impacts. Aleksandra Maziarz, Beata Kocan, Mariusz Bester, Sylwia Budzik, Marian Cholewa, Takahiro Ochiya and Agnieszka Banas.
In this article we review the current knowledge on the effects of EMFs on human adult stem cell biology, such as proliferation, the cell cycle, or differentiation.

Comparative study of magnetotherapy action in skin damages. Ingrid Soares, Paula Fernandes, Larissa Cordeiro, Hennes Gentil, Rodrigo Marcelvalentim, Sebastião David Santos-Filho, Patrícia Froes Meyer
Magnetic is a pulsed electromagnetic field that induces the formation of other electromagnetic fields perpendicular to their place of incidence, is a therapeutic resource of physiotherapy used for tissue repair. The study exposes the effects of Magnetic the healing process of diabetic rats. It was revealed that the healing process was accelerated by the application of Magnetic.

Effects of pulsed electromagnetic fields on peripheral blood circulation in people with diabetes: A randomized controlled trial. Jiahui Sun, Rachel Lai-Chu Kwan, Yongping Zheng,
Gladys Lai-Ying Cheing.
We examined the effects of pulsed electromagnetic fields (PEMFs) on cutaneous circulation of dorsal feet. Twenty-two patients with diabetes mellitus (DM) and 21 healthy control subjects were randomly allocated to receive either PEMFs or sham PEMFs (0.5 mT, 12 Hz, 30 min). Blood flow velocity and diameter of the small vein were examined by using ultrasound biomicroscopy; also, microcirculation at skin over the base of the 1st metatarsal bone (Flux1) and distal 1st phalange (Flux2) was measured by laser Doppler flowmetry before and after intervention. Results indicated that PEMFs produced significantly greater changes in blood flow velocity of the smallest observable vein than did sham PEMFs (both P < 0.05) in both types of subjects.

The use of a portable, wearable form of pulsed radio frequency electromagnetic energy device for the healing of recalcitrant ulcers: a case report. Rawe IM, Vlahovic TC.
Pulsed radio frequency energy (PRFE) has successfully been used to treat diabetic and venous stasis ulcers. In this case report, a lightweight wearable form of a PFRE device was evaluated and used to treat three diabetic foot ulcers and one venous stasis ulcer. A lightweight battery-powered, wearable form of PRFE device was introduced as a treatment and used 6-8 hours per day for a period of 6 weeks. All patients after 1 week of therapy showed improvement and wound size was seen to decrease. Patient 1 had a venous stasis ulcer, and reported significant pain relief after 2 weeks treatment. Patients 2 and 3 achieved complete healing after 3 weeks treatment, and patients 1 and 4 had a 95% and 88% reduction in wound size, respectively, after the 6-week study period. Both these patients continued to complete healing using the PRFE device after the 6-week study period. 


A portable pulsed electromagnetic field (PEMF) device to enhance healing of recalcitrant venous ulcers: a double-blind, placebo-controlled clinical trial. Stiller MJ, Pak GH, Shupack JL, Thaler S, Kenny C, Jondreau L.
A prospective, randomized, double-blind, placebo-controlled multicentre study assessed the clinical efficacy and safety of pulsed electromagnetic limb ulcer therapy (PELUT) in the healing of recalcitrant, predominantly venous leg ulcers. The portable device was used at home for 3 h daily during this 8-week clinical trial as an adjunct to a wound dressing. At week 8 the active group had a 47.7% decrease in wound surface area vs. a 42.3% increase for placebo (P < 0.0002). Investigators' global evaluations indicated that 50% of the ulcers in the active group healed or markedly improved vs. 0% in the placebo group, and 0% of the active group worsened vs. 54% of the placebo group (P < 0.001). Significant decreases in wound depth (P < 0.04) and pain intensity (P < 0.04) favouring the active group were seen.


Electromagnetic therapy for treating venous leg ulcers. Aziz Z, Cullum N.
Electromagnetic therapy (EMT) is sometimes used as a treatment to assist the healing of chronic wounds such as venous leg ulcers.  Three randomised controlled trials (RCTs) of low or unclear risk of bias, involving 94 people, were included in the original review; subsequent updates have identified no new trials. All the trials compared the use of EMT with sham-EMT. In the two trials that reported healing rates; one small trial (44 participants) reported that significantly more ulcers healed in the EMT group than the sham-EMT group however this result was not robust to different assumptions about the outcomes of participants who were lost to follow up. The second trial that reported numbers of ulcers healed found no significant difference in healing. The third trial was also small (31 participants) and reported significantly greater reductions in ulcer size in the EMT group however this result may have been influenced by differences in the prognostic profiles of the treatment groups.

A Wearable Device For Foot For Diabetic Neuropathy. Monali Madavi, G.H. Raisoni, Shubhangi Giripunje
In the proposed system, portable wearable in-shoe system (footwear) is designed. The temperature sensors or pressure sensors are being use to detect infected area. Here six to eight planter pressure sensors are implemented in sole of the shoe at various places like toe-area, metatarsal area, heel-area and mid-foot area. There are various types of sensors available in market for foot plantar pressure measurement which based on capacitance based, resistance based and voltage based. So, anyone from the above can be use here. Wirelessly output data of the various sensors can be transmitted to the hospital system as well as the doctor’s system and database is generated of the entire patient under treatment.

Therapeutic Effects of 15 Hz Pulsed Electromagnetic Field on Diabetic Peripheral Neuropathy in Streptozotocin-Treated RatsTao Lei, Da Jing, Kangning Xie1, Maogang Jiang, Feijiang Li, Jing Cai, Xiaoming Wu, Chi Tang, Qiaoling Xu, Juan Liu, Wei Guo, Janghao Shen, Erping Luo
Although numerous clinical studies have reported that pulsed electromagnetic fields (PEMF) have a neuroprotective role in patients with diabetic peripheral neuropathy (DPN), the application of PEMF for clinic is still controversial. The present study was designed to investigate whether PEMF has therapeutic potential in relieving peripheral neuropathic symptoms in streptozotocin (STZ)-induced diabetic rats.


Electrical stimulation and electromagnetic field use in patients with diabetic neuropathy: systematic review and meta-analysis.
Cinara Stein, Bruna Eibel, Graciele Sbruzzi, Pedro D. Lago, Rodrigo D. M. Plentz
We found that TENS improved pain relief in patients with diabetic neuropathy, while no such improvement was observed with the use of electromagnetic field treatment. Due to the  methodological differences between the studies, a meta-analysis for the outcome of sensitivity could not be performed.

The use of pulsed electromagnetic fields with complex modulation in the treatment of patients with diabetic polyneuropathy
. Musaev AV, Guseinova SG, Imamverdieva SS.
Clinical and electroneuromyographic studies were performed in 121 patients with diabetic polyneuropathy (DPN) before and after courses of treatment with pulsed electromagnetic fields with complex modulation (PEMF-CM) at different frequencies (100 and 10 Hz). PEMF-CM at 10 Hz was found to have therapeutic efficacy, especially in the initial stages of DPN and in patients with diabetes mellitus for up to 10 years.

Pulsed electromagnetic fields to reduce diabetic neuropathic pain and stimulate neuronal repair: a randomized controlled trial. Weintraub MI, Herrmann DN, Smith AG, Backonja MM, Cole SP.
To determine whether repetitive and cumulative exposure to low-frequency pulsed electromagnetic fields (PEMF) targeting painful feet can reduce neuropathic pain (NP), influence sleep in symptomatic diabetic peripheral neuropathy (DPN), and influence nerve regeneration. PEMF at this dosimetry was noneffective in reducing NP. However neurobiological effects on ENFD, PGIC and reduced itching scores suggest future studies are indicated with higher dosimetry (3000-5000 G), longer duration of exposure, and larger biopsy cohort.

Electrotherapy for the treatment of painful diabetic Peripheral neuropathy: a review. Karin Pieber, MD, Malvina Herceg, MD and Tatjana Paternostro-Sluga, MD, PhD. 
The efficacy of different types of electrotherapy for painful diabetic peripheral neuropathy has been evaluated in 15 studies; the effects of transcutaneous electrical nerve stimulation are consistent. The beneficial effects of prolonged use have been reported in three large studies and one small study. The effects of frequency-modulated electromagnetic neural stimulation were assessed in one large study, and a significant reduction in pain was reported.

And, finally, here is a link to one of the most cited sources:
Pulsed electromagnetic field therapy. History, state of the art and future. By Marko S. Markov 
 
13.01.2017, 10:44   MedGizmo
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